Journal article
Neural signatures of human fear conditioning: An updated and extended meta-analysis of fMRI studies
MA Fullana, BJ Harrison, C Soriano-Mas, B Vervliet, N Cardoner, A Àvila-Parcet, J Radua
Molecular Psychiatry | Published : 2016
DOI: 10.1038/mp.2015.88
Abstract
Classical Pavlovian fear conditioning remains the most widely employed experimental model of fear and anxiety, and continues to inform contemporary pathophysiological accounts of clinical anxiety disorders. Despite its widespread application in human and animal studies, the neurobiological basis of fear conditioning remains only partially understood. Here we provide a comprehensive meta-analysis of human fear-conditioning studies carried out with functional magnetic resonance imaging (fMRI), yielding a pooled sample of 677 participants from 27 independent studies. As a distinguishing feature of this meta-analysis, original statistical brain maps were obtained from the authors of 13 of these ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank the following authors for providing additional data or information not included in some original articles: M Andreatta, C Buchel, M Carter, H Critchley, J Dunsmoor, F Eippert, H Flor, J Hall, A Hermann, R Kalisch, J Kattoor, M Kindt, T Klucken, D Knight, TB Lonsdorf, M Menon, M Milad, C Merz, P Pauli, EA Phelps, L Romaniuk, D Schiller, D Schultz, V Spoormaker, R Stark, C Uhlmann, S van Well and R. Visser. This work was supported by 'Miguel Servet' contracts from the Carlos III Health Institute (Spain) to CS-M (CP10/00604) and JR (CP14/00041), grants from Carlos III Health Institute/FEDER to MAF/NC (PI12/00273) and CS-M (PI13/01958), and an Australian NHMRC Project Grant to BJH (APP1025619).